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This information does not affect patients taking casodex 50 mg daily for metastatic prostate cancer.

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Hepatic side effects including severe liver injury leading to hospitalization and death have been reported rarelyHepatitis or marked increases in liver enzymes leading to drug discontinuation have been reported in approximately 1of bicalutamide patientsOne case of fulminant hepatic failure associated with bicalutamide use has also been reportedRef]

Based on animal studiesCasodex can lead to inhibition of spermatogenesis and may impair fertility in males of reproductive potentialThe long-term effects of Casodex on male fertility have not been studiedsee Nonclinical Toxicology13.1

The safety and effectiveness of Casodex in pediatric patients have not been established.

Administration of Casodex may lead to inhibition of spermatogenesisThe long-term effects of Casodex on male fertility have not been studied.

Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use Casodex only for the indication prescribed.

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